吲哚与含导向基团的叔醇构建全碳季碳中心的对映选择性反应。
Enantioselective formation of all-carbon quaternary stereocenters from indoles and tertiary alcohols bearing a directing group.
机构信息
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR (China).
出版信息
Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1910-3. doi: 10.1002/anie.201405252. Epub 2014 Aug 1.
PMID:25088146
Abstract
Described is an efficient catalytic asymmetric intermolecular C-C bond-formation process to generate acyclic all-carbon quaternary stereocenters. The reactions overcome the unfavorable steric hindrance around reactive centers, and the competitive elimination (E1), to form a range of useful indole products with excellent efficiency and enantioselectivity.
摘要
本文描述了一种高效的催化不对称分子间 C-C 键形成过程，用于生成非循环全碳季立体中心。该反应克服了反应中心周围不利的空间位阻和竞争性消除（E1），以优异的效率和对映选择性形成了一系列有用的吲哚产物。
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