手性镍（II）配合物催化对映选择性一锅法合成4-色烯衍生物
Enantioselective one-pot synthesis of 4-chromene derivatives catalyzed by a chiral Ni(ii) complex.
作者信息
Yu Xuan, Lan Wenjie, Li Jiaqi, Bai Hui, Qin Zhaohai, Fu Bin
机构信息
Department of Applied Chemistry, China Agricultural University West Yuanmingyuan Rd. 2 Beijing 100193 People's Repubic of China
出版信息
RSC Adv. 2020 Dec 16;10(72):44437-44441. doi: 10.1039/d0ra08906k. eCollection 2020 Dec 9.
Abstract
A Ni(ii)-bis(oxazoline) complex and -TSOH are used to form enantioenriched 4-chromenes from -quinone methides (-QMs) and dicarbonyls, providing the desired products in up to 95% ee. The method is compatible with various β-ketoester substrates, and the products obtained could be converted into biologically active 4-chromene derivatives.
摘要
一种镍（II）-双恶唑啉配合物和对甲苯磺酸用于从醌甲基化物（-QMs）和二羰基化合物形成对映体富集的4-色烯，以高达95%的对映体过量提供所需产物。该方法与各种β-酮酯底物兼容，所得产物可转化为具有生物活性的4-色烯衍生物。
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