特发性点滴状色素减退症：一项电子显微镜研究。
Idiopathic guttate hypomelanosis: an electron microscopy study.
机构信息
Department of Dermatology, 'Henry Dunant' Hospital, Athens, Greece.
2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, 'Attikon' General University Hospital, Athens, Greece.
出版信息
J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1435-8. doi: 10.1111/jdv.12646. Epub 2014 Aug 4.
BACKGROUND
Few published data, concerning the electron microscopy findings of idiopathic guttate hypomelanosis have been published so far.
OBJECTIVES
To reveal the electron microscopic findings of idiopathic guttate hypomelanosis and their aetiopathogenetic associations.
METHODS
Punch biopsy specimens from four patients with idiopathic guttate hypomelanosis, after being properly processed, were observed under the electron microscope.
RESULTS
In the epidermis, melanocytes and melanosomes were normal in structure. In some areas, there was a reduced uptake of melanosomes by the keratinocytes. In the dermis, fibroblasts were structurally normal. Also, most elastic and collagen fibres were normal, but there were focal elastotic changes.
CONCLUSIONS
No significant structural abnormality of the melanocytes was observed, but rather a functional defect in the transfer of melanosomes from the melanocytes to the keratinocytes.
背景
目前，关于特发性滴状色素减退症的电子显微镜检查结果，仅有少量文献报道。
目的
揭示特发性滴状色素减退症的电子显微镜检查结果及其与发病机制的关联。
方法
对 4 例特发性滴状色素减退症患者进行了皮肤活检，标本经过适当处理后，在电子显微镜下进行观察。
结果
表皮中的黑素细胞和黑素小体结构正常。在某些区域，角质形成细胞对黑素小体的摄取减少。真皮中的成纤维细胞结构正常。此外，大多数弹性纤维和胶原纤维正常，但存在局灶性弹性组织变性。
结论
未观察到黑素细胞的明显结构异常，而是黑素小体从黑素细胞向角质形成细胞转移的功能缺陷。
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