Ploysangam T, Dee-Ananlap S, Suvanprakorn P
Lions Suphannahong Dermatology Clinic, Chulalongkorn Hospital, Bangkok, Thailand.
J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):681-4. doi: 10.1016/0190-9622(90)70273-k.
Idiopathic guttate hypomelanosis is a common skin disorder of unknown cause. Our studies have shown that significantly fewer dopa-positive melanocytes are in the white macules of idiopathic guttate hypomelanosis than in normal skin. By electron microscopy we observed that the melanocytes in the lesional skin were round and less dendritic with fewer melanosomes than in normal pigment cells. Lesions gently frozen with liquid nitrogen repigmented in 6 to 8 weeks. The number of dopa-positive melanocytes was significantly greater in the repigmented areas than in untreated lesions but less than in normal skin.
特发性点滴状色素减退症是一种病因不明的常见皮肤病。我们的研究表明，特发性点滴状色素减退症白色斑片中多巴阳性黑素细胞的数量明显少于正常皮肤。通过电子显微镜观察，我们发现病变皮肤中的黑素细胞呈圆形，树突较少，黑素小体比正常色素细胞少。用液氮轻轻冷冻的皮损在6至8周内重新色素沉着。重新色素沉着区域中多巴阳性黑素细胞的数量明显多于未治疗的皮损，但少于正常皮肤。
