α-羟基环庚三烯酚酮的生物学与合成
The biology and synthesis of α-hydroxytropolones.
作者信息
Meck Christine, D'Erasmo Michael P, Hirsch Danielle R, Murelli Ryan P
机构信息
Brooklyn College, City University of New York, Department of Chemistry, 2900 Bedford 4 Avenue, Brooklyn, New York, USA.
出版信息
Medchemcomm. 2014 Jul 1;5(7):842-852. doi: 10.1039/C4MD00055B.
Abstract
α-Hydroxytropolones are a subclass of the troponoid family of natural products that are of high interest due to their broad biological activity and potential as treatment options for several diseases. Despite this promise, there have been scarce synthetic chemistry-driven optimization studies on the molecules. The following review highlights key developments in the biological studies conducted on α-hydroxytropolones to date, including the few synthetic chemistry-driven optimization studies. In addition, we provide an overview of the methods currently available to access these molecules. This review is intended to serve as a resource for those interested in biological activity of α-hydroxytropolones, and inspire the development of new synthetic methods and strategies that could aid in this pursuit.
摘要
α-羟基环庚三烯酚酮是天然产物中环庚三烯酚酮家族的一个亚类，因其广泛的生物活性以及作为多种疾病治疗选择的潜力而备受关注。尽管有此前景，但针对这些分子的合成化学驱动的优化研究却很少。以下综述重点介绍了迄今为止对α-羟基环庚三烯酚酮进行的生物学研究中的关键进展，包括少数合成化学驱动的优化研究。此外，我们概述了目前可用于获取这些分子的方法。本综述旨在为那些对α-羟基环庚三烯酚酮的生物活性感兴趣的人提供参考资源，并激发有助于这一研究的新合成方法和策略的发展。
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