Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego Health System , San Diego, CA , USA.
Clin Toxicol (Phila). 2014 Aug;52(7):651-8. doi: 10.3109/15563650.2014.933231.
To analyze the contents of "bath salt" products purchased from California stores and the Internet qualitatively and quantitatively in a comprehensive manner.
A convenience sample of "bath salt" products were purchased in person by multiple authors at retail stores in six California cities and over the Internet (U.S. sites only), between August 11, 2011 and December 15, 2011. Liquid chromatography-time-of-flight mass spectrometry was utilized to identify and quantify all substances in the purchased products.
Thirty-five "bath salt" products were purchased and analyzed. Prices ranged from $9.95 to 49.99 (U.S. dollars). Most products had a warning against use. The majority (32/35, 91%) had one (n = 15) or multiple cathinones (n = 17) present. Fourteen different cathinones were identified, 3,4-methylenedioxypyrovalerone (MDPV) being the most common. Multiple drugs found including cathinones (buphedrone, ethcathinone, ethylone, MDPBP, and PBP), other designer amines (ethylamphetamine, fluoramphetamine, and 5-IAI), and the antihistamine doxylamine had not been previously identified in U.S. "bath salt" products. Quantification revealed high stimulant content and in some cases dramatic differences in either total cathinone or synthetic stimulant content between products with the same declared weight and even between identically named and outwardly appearing products.
Comprehensive analysis of "bath salts" purchased from California stores and the Internet revealed the products to consistently contain cathinones, alone, or in different combinations, sometimes in high quantity. Multiple cathinones and other drugs found had not been previously identified in U.S. "bath salt" products. High total stimulant content in some products and variable qualitative and quantitative composition amongst products were demonstrated.
全面、定性和定量地分析从加利福尼亚州商店和互联网购买的“浴盐”产品的内容。
作者在 2011 年 8 月 11 日至 12 月 15 日期间,在加利福尼亚州的六个城市的零售店和互联网(仅限美国网站)上,通过多个作者的便利抽样,亲自购买了“浴盐”产品。利用液相色谱-飞行时间质谱法鉴定和定量分析购买产品中的所有物质。
购买并分析了 35 种“浴盐”产品。价格范围从 9.95 美元到 49.99 美元(美元)。大多数产品都有使用警告。大多数(32/35,91%)含有一种(n=15)或多种卡他碱(n=17)。鉴定出 14 种不同的卡他碱,最常见的是 3,4-亚甲二氧基吡咯戊酮(MDPV)。发现了多种药物,包括卡他碱(丁丙诺啡、乙基卡他碱、乙基酮、MDPBP 和 PBP)、其他设计胺(乙基苯丙胺、氟苯丙胺和 5-IAI)和抗组胺药多西拉敏,这些药物以前都没有在美国的“浴盐”产品中被发现。定量分析显示,高刺激性含量,在某些情况下,即使是相同标称重量的产品,甚至是同名和外观相似的产品,其总卡他碱或合成刺激物含量也存在显著差异。
对从加利福尼亚州商店和互联网购买的“浴盐”进行综合分析显示,这些产品始终含有卡他碱,单独或不同组合,有时含量很高。在一些产品中发现了多种卡他碱和其他药物,这些药物以前没有在美国的“浴盐”产品中被发现。一些产品中总刺激物含量较高,产品之间的定性和定量组成存在差异。