血液白细胞介素-6 对脑卒中后功能结局预测的预后价值：系统评价和荟萃分析。
Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis.
机构信息
Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Spain; Neurology Department, Hospital Vall d'Hebron, Barcelona, Spain.
Department of Neurology, Clinical Neurosciences Research Laboratory, University Clinical Hospital, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.
出版信息
J Neuroimmunol. 2014 Sep 15;274(1-2):215-24. doi: 10.1016/j.jneuroim.2014.07.015. Epub 2014 Jul 24.
We aimed to quantify the association of blood interleukin-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR=2.346 (1.814-3.033), p<0.0001). However, the additional predictive value of IL-6 was moderate (IDI=1.5%, NRI=5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose.
我们旨在量化血液白细胞介素-6 (IL-6) 浓度与中风后不良预后的关联及其对临床信息的额外预测价值。对 24 项研究的荟萃分析证实了这种关联，加权平均差异为 3.443 (1.592-5.294) pg/mL，尽管存在高度异质性和发表偏倚。包括 4112 名中风患者的个体参与者数据表明，第 4 四分位的标准化 IL-6 水平与不良预后独立相关（OR=2.346 (1.814-3.033)，p<0.0001）。然而，IL-6 的额外预测价值适中（IDI=1.5%，NRI=5.35%）。总体而言，这些结果表明，IL-6 不太可能因此目的转化为临床实践。
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