Hasse Barbara, Bernasconi Enos, Furrer Hansjakob, Eyer Myriam M, Kovari Helen
Klinik für Infektionskrankheiten und Spitalhygiene, Universität und Universitätsspital Zürich.
Ospedale Regionale Lugano.
Ther Umsch. 2014 Aug;71(8):483-9. doi: 10.1024/0040-5930/a000541.
Antiretroviral therapy (ART) has improved quality of life and increased life expectancy of HIV-infected individuals. Opportunistic diseases are less common, and mortality has declined. Consequently, patterns of mortality and morbidity are changing among the HIV-positive population. The focus of care has shifted to ART-related problems and to various non-AIDS diseases. Such comorbidities, often occurring sequentially or concurrently, may be the consequences of long term ART toxicity, a state of chronic inflammation due to HIV infection, lifestyle-related risks for disease, and aging. The emergence of non-AIDS related conditions highlights the important role of primary care physicians, especially of those with extensive experience in HIV management.
抗逆转录病毒疗法(ART)提高了艾滋病毒感染者的生活质量并延长了预期寿命。机会性疾病变得不那么常见,死亡率也有所下降。因此,艾滋病毒阳性人群的死亡率和发病率模式正在发生变化。护理重点已转向与抗逆转录病毒疗法相关的问题以及各种非艾滋病疾病。这些合并症通常相继或同时出现,可能是长期抗逆转录病毒疗法毒性、艾滋病毒感染导致的慢性炎症状态、与生活方式相关的疾病风险以及衰老的结果。非艾滋病相关疾病的出现凸显了初级保健医生的重要作用,尤其是那些在艾滋病毒管理方面有丰富经验的医生。