细胞生物学：肌动蛋白在细胞间连接中度过了紧张但美好的一天。
Cell biology: a tense but good day for actin at cell-cell junctions.
作者信息
Nowotarski Stephanie H, Peifer Mark
机构信息
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA.
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Curr Biol. 2014 Aug 4;24(15):R688-90. doi: 10.1016/j.cub.2014.06.063.
Cells have evolved an elegant tuning mechanism to maintain tissue integrity, in which increasing mechanical tension stimulates actin assembly at cell-cell junctions. The mechanosensitive junctional protein α-catenin acts through vinculin and Ena/VASP proteins to reinforce the cell against mechanical stress.
细胞进化出了一种精妙的调节机制来维持组织完整性，其中增加的机械张力会刺激细胞间连接处以肌动蛋白组装。机械敏感连接蛋白α-连环蛋白通过纽蛋白和Ena/VASP蛋白发挥作用，以增强细胞抵抗机械应力的能力。
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