Festoff B W
Kansas City Veterans Administration Medical Center, MO 64128.
Neurobiol Aging. 1989 Sep-Oct;10(5):465-6; discussion 477-8. doi: 10.1016/0197-4580(89)90098-5.
The authors have provided us with a complete review of the approaches to the amyloid proteins of Alzheimer's disease in regards to targets for drug therapy. Sufficient information is now available concerning systemic amyloidogenesis, genes for familial Alzheimer's disease and the beta amyloid precursor protein, as well as the posttranslational processing requirements for amyloidogenesis and its prevention. Recent excitement concerning the roles for serine proteases and their inhibitors, both in the production and prevention of amyloidogenesis, make this review and its publication in the Neurobiology of Aging extremely timely.
作者为我们提供了一份关于阿尔茨海默病淀粉样蛋白药物治疗靶点研究方法的全面综述。目前，关于系统性淀粉样蛋白生成、家族性阿尔茨海默病相关基因和β淀粉样前体蛋白，以及淀粉样蛋白生成及其预防的翻译后加工要求，已有足够的信息。最近，丝氨酸蛋白酶及其抑制剂在淀粉样蛋白生成的产生和预防中的作用引发了人们的关注，这使得这篇综述及其在《衰老神经生物学》上的发表极为及时。
