精子形态、精液中总活动精子数以及精子样本中授精的活动精子数量对宫腔内人工授精成功率的影响。
The influence of sperm morphology, total motile sperm count of semen and the number of motile sperm inseminated in sperm samples on the success of intrauterine insemination.
作者信息
Nikbakht Roshan, Saharkhiz Nasrin
机构信息
Fertility and Infertility Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
出版信息
Int J Fertil Steril. 2011 Oct;5(3):168-73. Epub 2011 Dec 22.
BACKGROUND
The present study aimed to analyze the prognostic value of sperm morphology , total motile sperm count (TMSC) and the number of motile sperm inseminated (NMSI) on the outcome of intrauterine insemination (IUI).
MATERIALS AND METHODS
This cross sectional study was carried out 445 women undergoing 820 IUI cycles. All of the patients underwent controlled ovarian hyper stimulation with clomiphen citrate and human menopausal gonadotropin (HMG) followed by intrauterine insemination with the husband's sperm. Pregnancy rate (PR) per cycle in correlation to sperm morphology, TMSC and NMSI was obtained. Statistical analysis of the data was done by the SPSS version 13 (Chicago,USA).
RESULTS
A total of 81 clinical pregnancies were obtained for a pregnancy rate per cycle of 9.9%. When the TMSC was 5×10(6)to <10×10(6), the PR per cycle was significantly higher than the subgroups <1×10(6), 1×10(6)to <5×10(6)and ≥10×10(6)(15%, 5.6%, 5.1%, 10.8%, respectively). Sperm morphology was in itself a significant factor that affected the likelihood of IUI success. Nonetheless, the most significant difference of the PR per cycle with sperm morphology was in the subgroup <5 % (2.1% vs. 97.9%).When the NMSI was ≥10×10(6), the PR per cycle was significantly higher than the subgroups<5×10(6)and 5×10(6)to< 10× 10(6)(11.2%, 4.1%, 5.2%, respectively).
CONCLUSION
The study showed that TMSC 5×10(6)to < 10×10(6)and normal sperm morphology ≥ 5% and NMSI ≥ 10×10(6)are useful prognostic factors of IUI cycles.
背景
本研究旨在分析精子形态、总活动精子数（TMSC）以及授精活动精子数（NMSI）对宫腔内人工授精（IUI）结局的预后价值。
材料与方法
本横断面研究纳入了445名接受820个IUI周期的女性。所有患者均接受克罗米芬柠檬酸盐和人绝经期促性腺激素（HMG）控制性卵巢过度刺激，随后用丈夫的精子进行宫腔内人工授精。获得了每个周期与精子形态、TMSC和NMSI相关的妊娠率（PR）。数据采用SPSS 13版（美国芝加哥）进行统计分析。
结果
共获得81例临床妊娠，每个周期的妊娠率为9.9%。当TMSC为5×10⁶至<10×10⁶时，每个周期的PR显著高于<1×10⁶、1×10⁶至<5×10⁶和≥10×10⁶的亚组（分别为15%、5.6%、5.1%、10.8%）。精子形态本身是影响IUI成功可能性的一个重要因素。然而，每个周期PR与精子形态的最显著差异在于<5%的亚组（2.1%对97.9%）。当NMSI≥10×10⁶时，每个周期的PR显著高于<5×10⁶和5×10⁶至<10×10⁶的亚组（分别为11.2%、4.1%、5.2%）。
结论
研究表明，TMSC为5×10⁶至<10×10⁶、正常精子形态≥5%以及NMSI≥10×10⁶是IUI周期有用的预后因素。
Zotero 插件