Mohammadi Fatemeh, Mehdinia Zohreh, Ghasemi Samaneh, Zolfaghari Zahra, Amjadi Fatemeh Sadat, Ashrafi Mahnaz, Zandieh Zahra
Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
These two authors contributed equally to this article.
Caspian J Intern Med. 2021 Winter;12(1):70-76. doi: 10.22088/cjim.12.1.70.
Intrauterine insemination (IUI) is a widely utilized method for treating the infertile couples. The aim of the present study was to determine the pregnancy and abortion rates after IUI and to examine the relationship of sperm parameters with these rates.
This retrospective study was performed on 911 infertile couples undergoing IUI treatment in Shahid Akbarabadi IVF Centre from May 2017 to May 2019. To evaluate the correlation of sperm parameters with the clinical pregnancy and abortion rates, odds ratio (OR) with 95% confidence intervals (CI) was calculated.
In this study, the pregnancy rate following IUI was 15.7% (143/911), and among women who achieved pregnancy, the abortion rate was 42.0% (60/143). According to the multiple logistic regression analysis, none of the sperm parameters was associated with the pregnancy rate. Couples with either male or female factor infertility etiologies were more likely to get pregnant than those with unexplained infertility. Regarding the abortion rate, multiple logistic regression analysis revealed that normal sperm count was related to a lower abortion rate (adjusted OR=0.25, 95% CI=0.07-0.91).
The present study did not reveal a significant relationship between none of the sperm parameters and pregnancy rate after IUI treatment. However, among women who got pregnant, continuation of the pregnancy was associated with the normal sperm count. Furthermore, analysis of all semen parameters together in comparison to one parameter alone might be more accurate to predict pregnancy or abortion. Further prospective cohort studies with a large number of couples are required.
宫腔内人工授精（IUI）是治疗不孕夫妇的一种广泛应用的方法。本研究的目的是确定IUI后的妊娠率和流产率，并研究精子参数与这些比率之间的关系。
本回顾性研究对2017年5月至2019年5月在沙希德·阿克巴拉巴迪体外受精中心接受IUI治疗的911对不孕夫妇进行。为了评估精子参数与临床妊娠率和流产率的相关性，计算了比值比（OR）及95%置信区间（CI）。
在本研究中，IUI后的妊娠率为15.7%（143/911），在成功妊娠的女性中，流产率为42.0%（60/143）。根据多因素逻辑回归分析，没有一个精子参数与妊娠率相关。有男性或女性因素不孕病因的夫妇比不明原因不孕的夫妇更易怀孕。关于流产率，多因素逻辑回归分析显示正常精子计数与较低的流产率相关（校正OR=0.25，95%CI=0.07-0.91）。
本研究未发现IUI治疗后精子参数与妊娠率之间存在显著关系。然而，在怀孕的女性中，妊娠的持续与正常精子计数有关。此外，与单独分析一个参数相比，综合分析所有精液参数可能更准确地预测妊娠或流产。需要进一步开展大量夫妇参与的前瞻性队列研究。
