Walls E K, Koopmans H S
Department of Medical Physiology, University of Calgary, Alberta, Canada.
Physiol Behav. 1989 Jun;45(6):1223-6. doi: 10.1016/0031-9384(89)90113-3.
To assess the effect of gut signals on food intake two types of nutrients were infused intravenously for 17.5 hours in 17 hour fed rats. In the first experiment a solution of 25% d-glucose and 4.25% amino acids (Travasol) was infused at levels of 26 and 52 kcal/day for two consecutive four-day periods. During infusion periods, food intake was reduced from saline baseline levels by 18.9 +/- 1.7 and 34.8 +/- 1.8 kcal/day, respectively. This represents an oral intake reduction of approximately 70% of the infused calories. In contrast, food intake was reduced 17.4 +/- 1.7 kcal/day below saline baseline levels when 40 kcal of Nutralipid were infused. The reduction in food intake was only 43% of the lipid calories infused. These results indicate that infusions of glucose and amino acids are more effective than infusion of fats in inhibiting daily food intake, that gut signals associated with absorption of fat provide important satiety signals and that removal of fat from the bloodstream has relatively little effect on daily food intake.
为评估肠道信号对食物摄入的影响，在17小时进食的大鼠中静脉输注两种营养素，持续17.5小时。在第一个实验中，将25%的d-葡萄糖和4.25%的氨基酸溶液（特拉伐索）以26和52千卡/天的水平连续输注两个四天周期。在输注期间，食物摄入量分别比生理盐水基线水平降低了18.9±1.7和34.8±1.8千卡/天。这意味着口服摄入量减少了约70%的输注热量。相比之下，当输注40千卡的纽曲兰时，食物摄入量比生理盐水基线水平降低了17.4±1.7千卡/天。食物摄入量的减少仅为输注脂质热量的43%。这些结果表明，输注葡萄糖和氨基酸在抑制每日食物摄入方面比输注脂肪更有效，与脂肪吸收相关的肠道信号提供重要的饱腹感信号，并且从血液中清除脂肪对每日食物摄入的影响相对较小。
