卵巢颗粒细胞瘤诊断与治疗选择的综合综述

A comprehensive review of diagnostic and treatment options for granulosa cell tumors of the ovary.

作者信息

Stine Jessica E, Pierce Stuart, Soper John T

机构信息

Fellow Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.

Resident Obstetrics and Gynecology, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.

出版信息

Obstet Gynecol Surv. 2014 Jan;69(1):29-38. doi: 10.1097/OGX.0000000000000010.

DOI:10.1097/OGX.0000000000000010

PMID:25102249

Abstract

Granulosa cell tumors are rare and comprise approximately 2% to 8% of all ovarian malignancies. Research dedicated to these tumors is rare given the low incidence. These tumors are more difficult to diagnose than epithelial ovarian tumors, and understanding how they present may aid in appropriate referral to a gynecologic oncologist. The aim of this review was to summarize the epidemiology, risk factors, and clinical presentation of granulosa cell tumors to aid in provider recognition. We will also explore current diagnostic and treatment modalities with examination of newer, novel treatments. At the end of this review, the reader should understand how to appropriately diagnose and treat these rare malignancies.

摘要

颗粒细胞瘤较为罕见，约占所有卵巢恶性肿瘤的2%至8%。鉴于其发病率较低，针对这些肿瘤的研究也很少见。与上皮性卵巢肿瘤相比，这些肿瘤更难诊断，了解它们的表现形式可能有助于将患者适当地转诊给妇科肿瘤学家。本综述的目的是总结颗粒细胞瘤的流行病学、危险因素和临床表现，以帮助医生识别。我们还将探讨当前的诊断和治疗方式，并研究更新颖的治疗方法。在本综述结束时，读者应了解如何恰当地诊断和治疗这些罕见的恶性肿瘤。