Bezuglov V V, Gretskaia N M, Vasil'eva T M, Petrukhina G N, Andreeva L A, Miasoedov N F, Makarov V A
Eksp Klin Farmakol. 2014;77(6):30-2.
The influence two original derivatives of a therapeutically important peptide, bearing arachidonic acid residue with semax and proglyprol, upon platelet aggregation have been studied in vitro. It is established that both derivatives, in contrast to the parent peptide, possess moderate anti-aggregant properties and produce a dose-dependent decrease in the interplatelet interaction induced by ADP, epinephrine, and arachidonic acid within the concentration range of 0.018 - 1.8 mM. This activity was more pronounced for arachidonoylsemax in comparison with arachidonoylproglyprol.
在体外研究了一种具有治疗重要性的肽的两种原始衍生物，它们带有花生四烯酸残基以及赛美克斯（semax）和脯氨酰脯氨酸（proglyprol），对血小板聚集的影响。已确定，与母体肽相比，这两种衍生物均具有适度的抗聚集特性，并且在0.018 - 1.8 mM的浓度范围内，能使由ADP、肾上腺素和花生四烯酸诱导的血小板间相互作用呈剂量依赖性降低。与花生四烯酰脯氨酰脯氨酸相比，花生四烯酰赛美克斯（arachidonoylsemax）的这种活性更为明显。
