采用毛细管气相色谱-负离子化学电离质谱联用技术测定人血浆中利奥前列素的药代动力学。
Pharmacokinetics of rioprostil in human plasma as assayed by combined capillary gas chromatography-negative ion chemical ionization mass spectrometry.
作者信息
Fischer S, Schweer H, Kraft H, Weber P
机构信息
Medizinische Klinik Innenstadt der Universität München, FRG.
出版信息
Scand J Gastroenterol Suppl. 1989;164:59-61; discussion 61-2. doi: 10.3109/00365528909091188.
To investigate the pharmacokinetics of rioprostil in man an assay is developed to analyse levels of rioprostil in plasma. After extraction and purification by solid-phase cartridges rioprostil is measured by negative ion chemical ionization mass spectrometry using a deuterated internal standard. The method is validated by a recovery experiment. Levels of rioprostil in the plasma of four volunteers following a single oral dose of 600 micrograms rioprostil are found as always below 100 pg/ml. The data presented here suggest that rioprostil is transformed rapidly in man to its more polar metabolites.
为研究利奥前列素在人体中的药代动力学，开发了一种用于分析血浆中利奥前列素水平的检测方法。通过固相柱进行萃取和纯化后，使用氘代内标通过负离子化学电离质谱法测定利奥前列素。该方法通过回收率实验进行验证。四名志愿者单次口服600微克利奥前列素后，其血浆中利奥前列素水平始终低于100 pg/ml。此处提供的数据表明，利奥前列素在人体中迅速转化为极性更强的代谢产物。
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