UGT1A1*28基因多态性与儿童急性淋巴细胞白血病：一项丹麦病例对照研究。

UGT1A1*28 polymorphism and acute lymphoblastic leukemia in children: a Danish case-control study.

作者信息

Petersen Jesper P, Overvad Kim, Hollegaard Mads V, Ebbesen Finn, Henriksen Tine B, Thorlacius-Ussing Ole, Hougaard David M, Schrøder Henrik

机构信息

1] Pediatric Department, Aarhus University Hospital, Aarhus, Denmark [2] Pediatric Department, Aalborg University Hospital, Aalborg, Denmark.

Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.

出版信息

Pediatr Res. 2014 Nov;76(5):459-63. doi: 10.1038/pr.2014.115. Epub 2014 Aug 8.

DOI:10.1038/pr.2014.115

PMID:25105254

Abstract

BACKGROUND

Oxidative stress is a possible risk factor in the development of acute lymphoblastic leukemia (ALL) in children. Bilirubin is a potent endogenous antioxidant, and the UGT1A1*28 polymorphism is the main genetic cause of variation in plasma bilirubin in Western Europe.

METHODS

In a case-control study of 665 incident cases of ALL in childhood in Denmark 1982-2010 and 1,379 controls, associations between UGT1A1*28 genotypes and ALL in childhood were estimated as odds ratios by logistic regression with adjustment for sex and birth decade. Subgroup analyses were carried out by age at onset in three groups, and on the ALL subtypes precursor B-cell, T-cell, and t(12;21) positive status. Cases were identified in The Danish Registry of Childhood Cancer, and genotypes were estimated from dried blood spots stored in The Danish Neonatal Screening Biobank. Controls were newborns with blood spots taken right before and after a case.

RESULTS

We found no association between ALL in childhood and UGT1A1*28 genotypes. The odds ratio was 1.01 (0.88-1.17) for heterozygotes and 1.03 (0.78-1.36) for homozygotes. Also, no associations were found in the subgroup analyses.

CONCLUSION

We found no association between the UGT1A1*28 genotypes and ALL in children.

摘要

背景

氧化应激可能是儿童急性淋巴细胞白血病（ALL）发病的一个风险因素。胆红素是一种强效内源性抗氧化剂，而UGT1A1*28多态性是西欧血浆胆红素变异的主要遗传原因。

方法

在一项针对1982年至2010年丹麦665例儿童ALL发病病例和1379例对照的病例对照研究中，通过逻辑回归估计UGT1A1*28基因型与儿童ALL之间的关联，并对性别和出生年代进行调整，得出比值比。按发病年龄分为三组进行亚组分析，并对ALL亚型前体B细胞、T细胞和t(12;21)阳性状态进行分析。病例来自丹麦儿童癌症登记处，基因型从丹麦新生儿筛查生物银行储存的干血斑中估计。对照是在病例前后采集血斑的新生儿。