低围产锌状态与儿童 1 型糖尿病的发病风险无关。

Low perinatal zinc status is not associated with the risk of type 1 diabetes in children.

机构信息

Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Paediatrics, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Section of Biostatistics, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Pediatr Diabetes. 2017 Nov;18(7):637-642. doi: 10.1111/pedi.12476. Epub 2016 Nov 22.

DOI:10.1111/pedi.12476

PMID:27873432

Abstract

AIM

Immunologic events during fetal life may play a part in the pathogenesis of type 1 diabetes (T1D). As zinc is involved in immunologic processes, the purpose was to investigate perinatal zinc status and the later risk of developing T1D and association to age at onset.

METHODS

A population-based case-control study based on data from Danish Childhood Diabetes Register and the Danish Newborn Screening Biobank. Cases and controls were matched by birth year and month. Zinc status was analyzed in dried blood spots collected 5 to 7 days after birth. Logistic regression model was used to test the influence of zinc on risk of T1D. Linear regression modeling was used to examine the association between zinc status and covariates as well as age at onset. Zinc status was adjusted for HLA-DQB1 genotype, birth data and maternal age.

RESULTS

Each doubling in perinatal zinc status was not associated with T1D risk; odds ratio (OR) = 1.06 (95% confidence interval [CI] 0.84, 1.32) ( P = 0.62), adjusted for birth year and season. This finding persisted after adjustment for possible confounders; OR = 1.01 (95% CI 0.77, 1.34) ( P = 0.93). In none of the cohorts there were significant associations to age at onset.

CONCLUSION

The risk of developing T1D in Danish children was not associated with perinatal zinc status nor age at onset.

摘要

目的

胎儿期的免疫事件可能在 1 型糖尿病（T1D）的发病机制中起作用。由于锌参与免疫过程，本研究旨在调查围产期锌状况以及随后发生 T1D 的风险和与发病年龄的关系。

方法

本研究基于丹麦儿童糖尿病登记处和丹麦新生儿筛查生物库的数据，开展了一项基于人群的病例对照研究。病例和对照按出生年份和月份进行匹配。在出生后 5 至 7 天采集的干血斑中分析锌状况。使用逻辑回归模型检验锌对 T1D 风险的影响。线性回归模型用于检验锌状况与协变量以及发病年龄之间的关系。锌状况调整了 HLA-DQB1 基因型、出生数据和母亲年龄。

结果

围产期锌状况每增加一倍与 T1D 风险无关；比值比（OR）= 1.06（95%置信区间 [CI] 0.84，1.32）（P=0.62），校正了出生年份和季节。在校正了可能的混杂因素后，这一发现仍然存在；OR = 1.01（95%CI 0.77，1.34）（P=0.93）。在所有队列中，锌状况与发病年龄均无显著关联。