超排卵既不影响雌性后代小鼠子宫和乳腺的内分泌活动，也不会增加其对致癌作用的易感性。
Superovulation does not affect the endocrine activity nor increase susceptibility to carcinogenesis of uterine and mammary glands of female offspring in mice.
作者信息
Gao Zong, Zhang Gang, Yu Jing, Lu Xi-Lan, Li Jun-Tao, Zhang Jian-Min
机构信息
Department of Neurosurgery, Affiliated hospital of Shandong Tranditional Chinese Medicine University, Jinan, China.
出版信息
J Assist Reprod Genet. 2014 Sep;31(9):1243-9. doi: 10.1007/s10815-014-0295-z. Epub 2014 Aug 10.
PURPOSE
To evaluate the dual effects of superovulation on the endocrine activity and susceptibility to carcinogenesis of uterine and mammary glands of female offspring in mice
METHOD
The mice were superovaluted. The relative uterine weight, ERα protein expression, and endocrine activity of female offspring (F1 generation and F2 generation) were measured. Furthermore, proliferative lesion of uterine and mammary glands of female offspring (F1 generation and F2 generation) was assessed by histopathologic examinations.
RESULTS
There were no significant differences in relative uterine weight, ERα protein expression, incidence of proliferative lesion in mammary glands, and incidence of atypical hyperplasia, adenocarcinoma, and squamous metaplasia in uterine among the offspring (F1 generation and F2 generation) in each group. Likewise, there were no significant intergroup differences in the serum levels of sex related hormones.
CONCLUSIONS
No significant alterations were found in the endocrine activity and susceptibility to carcinogenesis of uterine and mammary glands of female offspring in mice produced by superovaluted oocytes compared with those of naturally conceived offspring.
目的
评估超排卵对小鼠雌性后代子宫和乳腺内分泌活性及致癌易感性的双重影响
方法
对小鼠进行超排卵处理。测量雌性后代（F1代和F2代）的相对子宫重量、ERα蛋白表达及内分泌活性。此外，通过组织病理学检查评估雌性后代（F1代和F2代）子宫和乳腺的增殖性病变。
结果
每组后代（F1代和F2代）中，相对子宫重量、ERα蛋白表达、乳腺增殖性病变发生率以及子宫非典型增生、腺癌和鳞状化生发生率均无显著差异。同样，血清性激素水平在组间也无显著差异。
结论
与自然受孕后代相比，超排卵卵母细胞产生的小鼠雌性后代子宫和乳腺的内分泌活性及致癌易感性未发现明显改变。
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