血小板衍生生长因子对人牙囊肿PGI2形成的增强作用及其在囊肿生长和骨吸收中的作用。

Enhancement of human dental cyst PGI2 formation by platelet derived growth factor and its role in cyst growth and bone resorption.

作者信息

Nell A, Mailath G, Porteder H, Ulrich W, Sinzinger H, Matejka M

机构信息

Department of Dentistry, University Clinic of Vienna, Dental School, Austria.

出版信息

Arch Oral Biol. 1989;34(3):187-90. doi: 10.1016/0003-9969(89)90006-x.

DOI:10.1016/0003-9969(89)90006-x

PMID:2510705

Abstract

Various prostaglandins, particularly PGE2 and PGI2, appear to play a major role in osteolytic processes. Radiochromatographic studies have demonstrated that 6-oxo-PGF1-alpha is a major product of exogenously added arachidonic acid in human dental cysts. As platelets may also act as inflammatory cells, platelet-derived growth factor might also have a PGI2-stimulating influence in such cysts. Eleven human dental cysts were examined by a radioimmunoassay and bioassay which can show PGI2 synthesis in human dental cysts without addition of PDGF. Incremental PDGF addition caused a highly significant increase in the rate of PGI2 synthesis. PGDF thus stimulates PGI2 synthesis in chronic inflammatory processes in vitro and may thereby elicit or accelerate osteolysis.

摘要

多种前列腺素，尤其是前列腺素E2和前列环素，似乎在溶骨过程中起主要作用。放射色谱研究表明，6-氧代前列腺素F1-α是人类牙囊肿中外源性添加花生四烯酸的主要产物。由于血小板也可能作为炎症细胞发挥作用，血小板衍生生长因子在这类囊肿中可能也对前列环素的合成有刺激作用。通过放射免疫测定法和生物测定法对11个人类牙囊肿进行了检测，这两种方法可以在不添加血小板衍生生长因子的情况下显示人类牙囊肿中的前列环素合成。添加递增剂量的血小板衍生生长因子导致前列环素合成速率显著提高。因此，血小板衍生生长因子在体外慢性炎症过程中刺激前列环素合成，从而可能引发或加速骨溶解。