Isobe T, Ichimura T, Okuyama T
Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Japan.
Arch Histol Cytol. 1989;52 Suppl:25-32. doi: 10.1679/aohc.52.suppl_25.
Studies of proteins specific to a certain type of cell are of general interest because these proteins may be involved in the determination of morphological and functional characteristics of the cell. In the nervous tissue, many "neuron-specific" and "glia-specific" proteins have been identified by various biochemical and immunohistochemical means and their relationships to cell functions have been studied. This paper briefly reviews our studies on the chemical and cell-biological aspects of the neuron- and glia-specific proteins, with special reference to the 14-3-3 protein and the S100 protein. Our studies suggest that glial protein S100 may be involved in the regulation of cell growth and differentiation, while neuronal protein 14-3-3, in the regulation of serotonin and catecholamine biosynthesis in neurons and other monoamine-synthesizing cells.
对特定类型细胞所特有的蛋白质进行研究具有普遍意义，因为这些蛋白质可能参与细胞形态和功能特征的决定。在神经组织中，通过各种生化和免疫组织化学方法已经鉴定出许多“神经元特异性”和“神经胶质特异性”蛋白质，并对它们与细胞功能的关系进行了研究。本文简要回顾了我们对神经元和神经胶质特异性蛋白质的化学和细胞生物学方面的研究，特别提及了14-3-3蛋白和S100蛋白。我们的研究表明，神经胶质蛋白S100可能参与细胞生长和分化的调节，而神经元蛋白14-3-3则参与神经元和其他单胺合成细胞中血清素和儿茶酚胺生物合成的调节。
