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SIRT1与内分泌因子之间的相互作用：对能量平衡的影响。

Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.

作者信息

Quiñones Mar, Al-Massadi Omar, Fernø Johan, Nogueiras Ruben

机构信息

Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), University of Santiago de Compostela, San Francisco s/n, Santiago de Compostela (A Coruña), 15782, and Avda. Barcelona 3, 15782, Santiago de Compostela, Spain.

Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), University of Santiago de Compostela, San Francisco s/n, Santiago de Compostela (A Coruña), 15782, and Avda. Barcelona 3, 15782, Santiago de Compostela, Spain.

出版信息

Mol Cell Endocrinol. 2014 Nov;397(1-2):42-50. doi: 10.1016/j.mce.2014.08.002. Epub 2014 Aug 7.

DOI:10.1016/j.mce.2014.08.002
PMID:25109279
Abstract

The mammalian sirtuins (SIRT1-7) are a family of highly conserved nicotine adenine dinucleotide (NAD(+))-dependent deacetylases that act as cellular sensors to detect energy availability. SIRT1 is a multifaceted protein that is involved in a wide variety of cellular processes. SIRT1 is activated in response to caloric restriction, acting on multiple targets in a wide range of tissues. SIRT1 regulates the role of multiple hormones implicated in energy balance, including glucose and lipid metabolism. Here, we review the relevant role of SIRT1 as a mediator of endocrine function of several hormones to modulate energy balance. In addition, we analyze the potential of targeting SIRT1 for the treatment of obesity and type 2 diabetes mellitus.

摘要

哺乳动物的沉默调节蛋白（SIRT1 - 7）是一类高度保守的烟酰胺腺嘌呤二核苷酸（NAD(+)）依赖性脱乙酰酶，作为细胞传感器来检测能量供应情况。SIRT1是一种多功能蛋白，参与多种细胞过程。SIRT1在热量限制的情况下被激活，作用于广泛组织中的多个靶点。SIRT1调节多种与能量平衡相关的激素的作用，包括葡萄糖和脂质代谢。在此，我们综述SIRT1作为几种激素内分泌功能的介质在调节能量平衡方面的相关作用。此外，我们分析了靶向SIRT1治疗肥胖症和2型糖尿病的潜力。

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[1]
Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.

Mol Cell Endocrinol. 2014-11

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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Exp Clin Endocrinol Diabetes. 2016-3

[9]
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[10]
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Biochem Cell Biol. 2010-8

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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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