Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain.
Int J Mol Sci. 2021 Jan 31;22(3):1430. doi: 10.3390/ijms22031430.
Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balance.
Sirtuins 是依赖 NAD+的去乙酰化酶，可调节大量生理过程。这些酶高度保守，作为能量传感器，以可控的方式协调不同的代谢反应。目前已经鉴定出 7 种哺乳动物的 sirtuins（SIRT1-7），其中 SIRT1 和 SIRT6 被证明在下丘脑发挥其代谢作用，两者在引发反应以减轻与肥胖相关的代谢并发症方面都起着至关重要的作用。因此，我们的目的是综述 SIRT1 和 SIRT6 在下丘脑的作用的现有认识，特别是强调它们在能量平衡控制方面的作用。
