Duclos C, Dumont M, Wiseman-Hakes C, Arbour C, Mongrain V, Gaudreault P-O, Khoury S, Lavigne G, Desautels A, Gosselin N
Center for advanced research in sleep medicine, hôpital du Sacré-Coeur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec, H4J 1C5, Canada.
Center for advanced research in sleep medicine, hôpital du Sacré-Coeur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec, H4J 1C5, Canada; Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, Québec, Canada.
Pathol Biol (Paris). 2014 Oct;62(5):252-61. doi: 10.1016/j.patbio.2014.05.014. Epub 2014 Aug 7.
Traumatic brain injury (TBI) is a major health concern in industrialised countries. Sleep and wake disturbances are among the most persistent and disabling sequelae after TBI. Yet, despite the widespread complaints of post-TBI sleep and wake disturbances, studies on their etiology, pathophysiology, and treatments remain inconclusive. This narrative review aims to summarise the current state of knowledge regarding the nature of sleep and wake disturbances following TBI, both subjective and objective, spanning all levels of severity and phases post-injury. A second goal is to outline the various causes of post-TBI sleep-wake disturbances. Globally, although sleep-wake complaints are reported in all studies and across all levels of severity, consensus regarding the objective nature of these disturbances is not unanimous and varies widely across studies. In order to optimise recovery in TBI survivors, further studies are required to shed light on the complexity and heterogeneity of post-TBI sleep and wake disturbances, and to fully grasp the best timing and approach for intervention.
创伤性脑损伤（TBI）是工业化国家主要的健康问题。睡眠和觉醒障碍是TBI后最持久且致残的后遗症之一。然而，尽管TBI后睡眠和觉醒障碍的主诉普遍存在，但关于其病因、病理生理学及治疗的研究仍无定论。本叙述性综述旨在总结TBI后睡眠和觉醒障碍性质的当前知识状态，包括主观和客观方面，涵盖所有严重程度级别及损伤后的各个阶段。第二个目标是概述TBI后睡眠-觉醒障碍的各种原因。在全球范围内，尽管所有研究都报告了睡眠-觉醒主诉，且涵盖所有严重程度级别，但关于这些障碍客观性质的共识并不一致，不同研究之间差异很大。为了优化TBI幸存者的康复，需要进一步研究以阐明TBI后睡眠和觉醒障碍的复杂性和异质性，并充分掌握最佳的干预时机和方法。
