Hatake K, Wakabayashi I, Kakishita E, Taniguchi T, Ouchi H, Sakaki N, Hishida S
Department of Legal Medicine, Hyogo College of Medicine, Japan.
Eur J Pharmacol. 1989 Sep 22;168(3):277-83. doi: 10.1016/0014-2999(89)90788-7.
The effect of ethanol was studied on the endothelium-dependent vascular responses in isolated rat aortic strips. Ethanol depressed the endothelium-dependent relaxation induced by acetylcholine and ATP but not that induced by the calcium ionophore, A23187. Endothelium-independent relaxation in response to sodium nitroprusside, a soluble guanylate cyclase activator, was not depressed by ethanol. On the other hand, ethanol significantly enhanced the contractile response to clonidine, an alpha 2-adrenoceptor agonist, in endothelium-intact strips and depressed it in endothelium-denuded strips. These results suggest that ethanol can inhibit endothelium-dependent relaxation by acting on endothelial cells but not on smooth muscle cells, and can also suppress an inhibitory effect of the endothelium on alpha 2-adrenoceptor-mediated vasoconstriction.
研究了乙醇对离体大鼠主动脉条内皮依赖性血管反应的影响。乙醇抑制了乙酰胆碱和ATP诱导的内皮依赖性舒张，但不抑制钙离子载体A23187诱导的舒张。对可溶性鸟苷酸环化酶激活剂硝普钠的非内皮依赖性舒张不受乙醇抑制。另一方面，乙醇显著增强了内皮完整条带对α2肾上腺素能受体激动剂可乐定的收缩反应，而在去内皮条带中则抑制了该反应。这些结果表明，乙醇可通过作用于内皮细胞而非平滑肌细胞来抑制内皮依赖性舒张，并且还可抑制内皮对α2肾上腺素能受体介导的血管收缩的抑制作用。
