Hatake K, Wakabayashi I, Hishida S
Department of Hygiene, Hyogo College of Medicine, Japan.
Eur J Pharmacol. 1993 Jul 20;238(2-3):441-4. doi: 10.1016/0014-2999(93)90883-j.
Using isolated rat aortic strips, we investigated the inhibitory effect of ethanol on endothelium-dependent relaxation induced by acetylcholine, especially on that mediated by endothelium-derived relaxing factor. Ethanol depressed the relaxation induced by acetylcholine and inhibited the increase in the content of intravascular cyclic GMP induced by acetylcholine, but not that induced by sodium nitroprusside or calcimycin. Ethanol also inhibited the acetylcholine-induced relaxation resistant to nitro-L-arginine. These results suggest that ethanol can inhibit the cyclic GMP-dependent relaxation mediated by endothelium-derived relaxing factor. Furthermore, ethanol seems to depress the cyclic GMP-independent relaxation mechanism.
利用离体大鼠主动脉条，我们研究了乙醇对乙酰胆碱诱导的内皮依赖性舒张的抑制作用，特别是对内皮源性舒张因子介导的这种作用。乙醇抑制了乙酰胆碱诱导的舒张，并抑制了乙酰胆碱诱导的血管内环状鸟苷酸（cGMP）含量的增加，但不抑制硝普钠或离子霉素诱导的增加。乙醇还抑制了对硝基-L-精氨酸有抗性的乙酰胆碱诱导的舒张。这些结果表明，乙醇可以抑制内皮源性舒张因子介导的cGMP依赖性舒张。此外，乙醇似乎还抑制了cGMP非依赖性舒张机制。
