Bin-Nun Alona, Booms Christina, Sabag Naama, Mevorach Refael, Algur Nurit, Hammerman Cathy
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.
Department of Neonatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Am J Perinatol. 2015 Mar;32(4):337-42. doi: 10.1055/s-0034-1384640. Epub 2014 Aug 11.
The aim of this study is to compare fecal calprotectin (FC) levels as measured by a rapid FC assay with those measured by enzyme-linked immunosorbent assay (ELISA) from concurrent stool samples. We also attempted to demonstrate a correlation between elevated rapid assay FC levels and the presence of necrotizing enterocolitis (NEC) and to define a cutoff FC value which could serve as a basis for diagnosing NEC in the future.
Stool samples were collected for FC analysis at 1 and 3 weeks postnatally and whenever there was clinical suspicion of NEC.
Rapid assay FC levels were elevated with NEC (3,000 µg/g stool [2075,7875] vs. without (195 µg/g stool [110,440] p < 0.001); and were well correlated with ELISA FC levels (r(2) = 0.89).
We present the first data showing that rapid assay FC levels are potentially useful in the bedside diagnosis of NEC.
本研究旨在比较通过快速粪便钙卫蛋白（FC）检测法与酶联免疫吸附测定（ELISA）法检测同期粪便样本所得的FC水平。我们还试图证明快速检测法测得的FC水平升高与坏死性小肠结肠炎（NEC）的存在之间的相关性，并确定一个FC临界值，作为未来诊断NEC的依据。
在出生后1周和3周以及临床怀疑有NEC时收集粪便样本进行FC分析。
NEC患者的快速检测法FC水平升高（3000μg/g粪便[2075,7875]），无NEC患者的FC水平为（195μg/g粪便[110,440]，p<0.001）；且与ELISA法测得的FC水平高度相关（r(2)=0.89）。
我们首次提供的数据表明，快速检测法测得的FC水平在NEC的床旁诊断中可能有用。
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