一种在室温下能自发释放苄基阳离子等价物的新型苄基化试剂的研发。

Development of a new benzylating reagent spontaneously releasing benzyl cation equivalents at room temperature.

作者信息

Yamada Kohei, Tsukada Yuichi, Karuo Yukiko, Kitamura Masanori, Kunishima Munetaka

机构信息

Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 (Japan).

出版信息

Chemistry. 2014 Sep 15;20(38):12274-8. doi: 10.1002/chem.201403158. Epub 2014 Aug 8.

DOI:10.1002/chem.201403158

PMID:25111963

Abstract

A new O-benzylating reagent, that is, 4-(4,6-diphenoxy-1,3,5-triazin-2-yl)-4-benzylmorpholinium trifluoromethanesulfonate (DPT-BM), has been developed. Benzyl cation equivalents are generated from DPT-BM by dissolving the compound in a solvent at room temperature under non-acidic conditions. The benzylation of various alcohols by using a combination of DPT-BM and magnesium oxide provided the benzyl ethers in good yields.

摘要

一种新型的O-苄基化试剂，即4-(4,6-二苯氧基-1,3,5-三嗪-2-基)-4-苄基吗啉三氟甲磺酸盐(DPT-BM)已被开发出来。通过在室温下将该化合物溶解在非酸性条件下的溶剂中，从DPT-BM生成苄基阳离子等价物。使用DPT-BM和氧化镁的组合对各种醇进行苄基化反应，以良好的产率得到了苄基醚。