Li Zhanzhan, Li Yanyan, Chen Lizhang
Department of Epidemiology and Health Statistics, School of Public Health, Central South University , Changsha, Hunan Province , China and.
Ren Fail. 2014 Nov;36(10):1473-80. doi: 10.3109/0886022X.2014.947517. Epub 2014 Aug 12.
A role for transforming growth factor-β1gene has been suggested in the etiology of IgA nephropathy. However, results have been inconsistent. In this study, a meta-analysis was performed to further clarify the association between transforming growth factor-β1-509C/T gene polymorphism and the susceptibility of IgA nephropathy. PubMed, EMBASE, Web of Science, CNKI, WanFang, and VIP Data were searched for eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals were calculated using a fixed-effects model or random-effects model. A total of eight publications involving 1355 IgA nephropathy patients and 1464 controls met the inclusion and were analyzed. The pooled ORs for the association between TGF-β1gene-509C/T polymorphism and IgA nephropathy risk were not statistically significant under all genetic models (for CT+TT vs. CC: OR = 1.09; 95% CI = 0.92-1.29, p = 0.490; for TT vs. CT+CC: OR = 1.14; 95% CI = 0.94-1.38, p = 0.081; for CC vs. TT: OR = 0.87; 95% CI = 0.69-1.08, p = 0.195; for C allele vs. T allele: OR = 0.92; 95% CI = 0.83-1.03, p = 0.149). In the stratified analysis by ethnicity, results also showed no significant association between TGF-β1 gene-509C/T polymorphism and IgA nephropathy risk in both European and Asian populations. This meta-analysis does not support the hypothesis that TGF-β1 gene-509C/T polymorphism is a risk factor for the development of IgA nephropathy.
转化生长因子-β1基因在IgA肾病的病因学中可能发挥作用。然而，研究结果并不一致。在本研究中，进行了一项荟萃分析以进一步阐明转化生长因子-β1 -509C/T基因多态性与IgA肾病易感性之间的关联。检索了PubMed、EMBASE、Web of Science、中国知网、万方和维普数据库中的符合条件的研究。使用固定效应模型或随机效应模型计算合并比值比（OR）及95%置信区间。共有8篇涉及1355例IgA肾病患者和1464例对照的文献符合纳入标准并进行分析。在所有遗传模型下，TGF-β1基因-509C/T多态性与IgA肾病风险之间的合并OR无统计学意义（CT + TT与CC相比：OR = 1.09；95% CI = 0.92 - 1.29，p = 0.490；TT与CT + CC相比：OR = 1.14；95% CI = 0.94 - 1.38，p = 0.081；CC与TT相比：OR = 0.87；95% CI = 0.69 - 1.08，p = 0.195；C等位基因与T等位基因相比：OR = 0.92；95% CI = 0.83 - 1.03，p = 0.149）。在按种族分层分析中，结果还显示在欧洲和亚洲人群中，TGF-β1基因-509C/T多态性与IgA肾病风险之间均无显著关联。该荟萃分析不支持TGF-β1基因-509C/T多态性是IgA肾病发生风险因素的假设。
