磷脂酰肌醇-3激酶（PI3K）、丝裂原活化蛋白激酶（MAPK）的细胞外信号调节激酶1/2（ERK1/2）和p38在碱性成纤维细胞生长因子的影响下参与间充质祖细胞生长潜能的实现。
PI3K, MAPK EPK1/2 and p38 are involved in the realization of growth potential of mesenchymal progenitor cells under the influence of basic fibroblast growth factor.
作者信息
Zyuz'kov G N, Danilets M G, Ligacheva A A, Zhdanov V V, Udut E V, Miroshnichenko L A, Simanina E V, Chaikovskii A V, Trofimova E S, Minakova M Yu, Udut V V, Dygai A M
机构信息
Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia,
出版信息
Bull Exp Biol Med. 2014 Aug;157(4):436-9. doi: 10.1007/s10517-014-2584-z. Epub 2014 Aug 12.
We studied PI3K, MAPK/EPK1/2 and p38-dependent signaling cascade under stimulation of the functions of mesenchymal progenitor cells by fibroblast growth factor. The important role of PI3K and EPK1/2 in the realization of their growth potential has been revealed. Experiments have demonstrated a blocking effect of PI3K inhibitor on proliferation and differentiation of progenitor cells and EPK1/2 inhibitor on mitotic activity of the progenitor cells. The p38-mediated MAPK pathway did not play a role in determining the proliferative and differentiation status of fibroblast CFU.
我们研究了在成纤维细胞生长因子刺激间充质祖细胞功能的情况下，磷脂酰肌醇-3激酶（PI3K）、丝裂原活化蛋白激酶/细胞外信号调节激酶1/2（MAPK/EPK1/2）和p38依赖的信号级联反应。已揭示PI3K和EPK1/2在实现其生长潜能中发挥的重要作用。实验证明PI3K抑制剂对祖细胞的增殖和分化具有阻断作用，而EPK1/2抑制剂对祖细胞的有丝分裂活性具有阻断作用。p38介导的MAPK途径在决定成纤维细胞集落形成单位（CFU）的增殖和分化状态方面不起作用。
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