PI3K、MAPK/ERK 1/2和p38在失血后骨髓细胞产生促红细胞生成活性中的作用。
Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.
作者信息
Zhdanov V V, Miroshnichenko L A, Udut E V, Zyuz'kov G N, Khrichkova T Yu, Simanina E V, Sherstoboev E Yu, Stavrova L A, Agafonov V I, Chaikovskii A V, Minakova M Yu, Dygai A M
机构信息
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
出版信息
Bull Exp Biol Med. 2016 Nov;162(1):51-55. doi: 10.1007/s10517-016-3543-7. Epub 2016 Nov 23.
The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.
在失血性贫血条件下，经典的丝裂原活化蛋白激酶途径（ERK途径）在调节贴壁骨髓细胞的红细胞生成活性中起主导作用。促红细胞生成素不是贴壁细胞红细胞生成活性形成的决定性因素。在循环血容量损失30%后，PI3K、MAPK/ERK 1/2和p38信号蛋白不是促红细胞生成素局部产生的主要调节因子。
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