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宫颈神经内分泌癌表现为副肿瘤性抗利尿激素分泌异常综合征导致的顽固性低钠血症性癫痫发作——1例罕见病例报告及文献简要综述

Neuroendocrine carcinoma of the cervix presenting as intractable hyponatremic seizures due to paraneoplastic SIADH-a rare case report and brief review of the literature.

作者信息

Kuriakose Santhosh, Umadevi N, Mathew Sheela, Supriya Nk, Aravindan Kp, Smitha Ds, Amritha Malini G

机构信息

Government Medical College, Medical College P.O., Kozhikode, Kerala 673001, India.

出版信息

Ecancermedicalscience. 2014 Jul 31;8:450. doi: 10.3332/ecancer.2014.450. eCollection 2014.

Abstract

Herein is presented an interesting case of small-cell neuroendocrine carcinoma of the cervix which initially manifests as seizures due to hyponatremia caused by paraneoplastic syndrome of inappropriate anti diuretic hormone (SIADH). Awareness of a paraneoplastic syndrome at presentation can lead to early diagnosis and early initiation of treatment. The management is also unique in that it combines treating the paraneoplastic aspects as well as targeting the tumour itself. Multimodality treatment gives the best outcome in this aggressive tumour.

摘要

本文介绍了一例有趣的宫颈小细胞神经内分泌癌病例,该病例最初表现为因抗利尿激素分泌异常综合征(SIADH)引起的低钠血症导致的癫痫发作。在就诊时意识到副肿瘤综合征可导致早期诊断和早期开始治疗。其治疗也很独特,因为它既包括治疗副肿瘤方面,也包括针对肿瘤本身。多模式治疗对这种侵袭性肿瘤能取得最佳疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60fd/4118728/f863408bf9df/can-8-450fig1.jpg

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