Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
J Int Med Res. 2021 Feb;49(2):300060520985657. doi: 10.1177/0300060520985657.
Small cell carcinoma of the cervix is a rare malignant tumor in the clinical setting. Clinical manifestations of this tumor are mostly similar to those of normal types of cervical cancer. Small cell carcinoma of the cervix only shows symptoms of neuroendocrine tumors, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Most of the hyponatremia caused by SIADH can be managed after removal of the cause. Hyponatremia is a predictor of poor prognosis and can be used as an indicator of partial recurrence. We report a case of small cell carcinoma of the cervix complicated by SIADH. Our patient presented with irregular vaginal bleeding after menopause. After one cycle of chemotherapy, there was trembling of the limbs, and a laboratory examination showed low Na and low Cl levels. After limited water intake, intravenous hypertonic saline, and intermittent diuretic treatment, the patient's blood Na levels returned to normal. After a radical operation, the above-mentioned symptoms disappeared.
宫颈小细胞癌是临床罕见的恶性肿瘤，该肿瘤的临床表现多与普通型宫颈癌相似，宫颈小细胞癌仅表现为神经内分泌肿瘤的症状，如抗利尿激素不适当分泌综合征（SIADH）。大多数由 SIADH 引起的低钠血症在去除病因后可得到控制。低钠血症是预后不良的预测因子，可作为部分复发的指标。我们报告了一例宫颈小细胞癌并发 SIADH 的病例。我们的患者在绝经后出现不规则阴道出血。化疗 1 个周期后出现四肢震颤，实验室检查发现低钠低氯。限制水摄入、静脉滴注高渗盐水和间断使用利尿剂治疗后，患者血钠水平恢复正常。根治性手术后，上述症状消失。
