Dive Daniel, Biot Christophe
Universite Lille 1, Unite de Glycobiologie Structurale et Fonctionnelle, UGSF, F-59650 Villeneuve d'Ascq, France.
Curr Top Med Chem. 2014;14(14):1684-92. doi: 10.2174/1568026614666140808122329.
Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.
在抗疟药铁喹啉的研发过程中,我们对其具体作用机制形成了许多观点。这些观点使我们能够提出若干实验,以验证有关铁喹啉与氯喹之间差异及其各自作用机制的这些假说的有效性。我们现已建立了一种终极理论,该理论调和了铁喹啉的氢键和氧化还原机制假说,并符合更广泛的已发表实验结果。