Bouquier Julie, Huchon Cyrille, Panel Pierre, Fauconnier Arnaud
From the *INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Paris, France, †Department of Gynecology & Obstetrics, Centre Hospitalier Intercommunal de Poissy-Saint-Germain, Research Unit EA 7285 "Risk and safety in clinical medicine for women and perinatal health," University of Versailles Saint-Quentin (UVSQ), Poissy, France; and ‡Department of Gynecology & Obstetrics, Centre Hospitalier André Mignot', Versailles, France.
Sex Transm Dis. 2014 Sep;41(9):525-31. doi: 10.1097/OLQ.0000000000000169.
Pelvic inflammatory disease (PID) is often responsible for acute pelvic pain, yet its clinical diagnosis is difficult. The aim of this study was to develop and validate prediction rules for the diagnosis of PID in patients seen for acute pelvic pain, based solely on a self-assessed questionnaire.
From September 2006 to April 2008, 499 consecutive patients presenting at the gynecology emergency departments of 5 hospitals for acute pelvic pain completed a Self-Assessment Questionnaire for Gynecological Emergencies. Seventy-three were identified as having a PID. Two-thirds of the database was randomly selected for the derivation of the prediction rules, and the other third was used for internal validation. We developed 2 scores, one that rules out a diagnosis of PID and one that predicts PID, based on multiple logistic regression with jackknife estimates. These scores were then validated with the validation data set.
Four variables were independently associated with PID: scattered pain radiation and/or diffuse pain, insidious pain, peritoneal irritation, and abnormal vaginal discharge. They were used to create a sensitive prediction model that rules out PID. Four other variables were used to build another model that predicted PID with high specificity: abnormal vaginal discharge, bilateral pelvic pain, constipation, and presence of an intrauterine device. The probability of PID for the patients in the low-risk group was 1.1% (95% confidence interval, 0.03-5.8), and the probability of PID in the high-risk group was 55% (95% confidence interval, 31.5-76.9).
These 2 prediction rules that classify patients in low risk or high risk of PID, based on simple items collected by a self-assessed questionnaire that are composed only of case history and autodescription of the pain, may prove useful for diagnosing or ruling out PID in patients with acute pelvic pain.
盆腔炎性疾病(PID)常导致急性盆腔疼痛,但其临床诊断困难。本研究的目的是仅基于一份自我评估问卷,制定并验证急性盆腔疼痛患者PID诊断的预测规则。
2006年9月至2008年4月,5家医院妇科急诊科连续收治的499例因急性盆腔疼痛就诊的患者完成了一份妇科急诊自我评估问卷。其中73例被诊断为PID。随机选取三分之二的数据库用于推导预测规则,其余三分之一用于内部验证。我们基于多重逻辑回归和刀切估计法制定了2个评分,一个用于排除PID诊断,另一个用于预测PID。然后用验证数据集对这些评分进行验证。
4个变量与PID独立相关:疼痛放射分散和/或弥漫性疼痛、隐痛、腹膜刺激征和异常阴道分泌物。它们被用于创建一个排除PID的敏感预测模型。另外4个变量用于构建另一个具有高特异性的预测PID的模型:异常阴道分泌物、双侧盆腔疼痛、便秘和宫内节育器的存在。低风险组患者患PID的概率为1.1%(95%置信区间,0.03 - 5.8),高风险组患者患PID的概率为55%(95%置信区间,31.5 - 76.9)。
这2个预测规则基于一份仅由病史和疼痛自我描述组成的自我评估问卷收集的简单项目,将患者分为PID低风险或高风险组,可能有助于诊断或排除急性盆腔疼痛患者的PID。