Chon Young Eun, Jung Kyu Sik, Kim Kwang Joon, Joo Dong Jin, Kim Beom Kyung, Park Jun Yong, Kim Do Young, Ahn Sang Hoon, Han Kwang-Hyub, Kim Seung Up
Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Korea.
Dig Dis Sci. 2015 Jan;60(1):234-42. doi: 10.1007/s10620-014-3293-1. Epub 2014 Aug 14.
BACKGROUND/AIMS: The controlled attenuation parameter (CAP) is a noninvasive method of assessing hepatic steatosis. We defined the normal range of CAP values in healthy subjects and evaluated the associated factors.
CAP values were measured in a cohort of healthy subjects who were screened as living liver transplantation donors and those who underwent health checkups. Subjects with current or a history of chronic liver disease, abnormalities on liver-related laboratory tests, or fatty liver on ultrasonography or biopsy were excluded.
The mean age of the 264 recruited subjects (131 males and 133 females; 76 potential liver donors and 188 subjects who had undergone health checkups) was 49.2 years. The mean CAP value was 224.8 ± 38.7 dB/m (range 100.0-308.0 dB/m), and the range of normal CAP values (5th-95th percentiles) was 156.0-287.8 dB/m. The mean CAP value was significantly higher in the health checkup than in the potential liver donor group (227.5 ± 42.0 vs. 218.2 ± 28.3 dB/m, P = 0.040). CAP values did not differ significantly according to gender or age in either group (all P > 0.05). In a multivariate linear regression analysis, body mass index (β = 0.271, P = 0.024) and triglyceride levels (β = 0.348, P = 0.008) were found to be independently associated with CAP values.
We determined the normal range of CAP values and found that body mass index and triglyceride levels were associated with the CAP values of healthy subjects.
背景/目的：受控衰减参数（CAP）是一种评估肝脂肪变性的非侵入性方法。我们定义了健康受试者CAP值的正常范围，并评估了相关因素。
在一组被筛选为活体肝移植供体的健康受试者以及接受健康检查的受试者中测量CAP值。排除患有当前或既往慢性肝病、肝脏相关实验室检查异常、超声检查或活检显示脂肪肝的受试者。
招募的264名受试者（131名男性和133名女性；76名潜在肝供体和188名接受健康检查的受试者）的平均年龄为49.2岁。平均CAP值为224.8±38.7 dB/m（范围100.0 - 308.0 dB/m），正常CAP值范围（第5 - 95百分位数）为156.0 - 287.8 dB/m。健康检查组的平均CAP值显著高于潜在肝供体组（227.5±42.0 vs. 218.2±28.3 dB/m，P = 0.040）。两组中CAP值在性别或年龄方面均无显著差异（所有P>0.05）。在多变量线性回归分析中，发现体重指数（β = 0.271，P = 0.024）和甘油三酯水平（β = 0.348，P = 0.008）与CAP值独立相关。
我们确定了CAP值的正常范围，并发现体重指数和甘油三酯水平与健康受试者的CAP值相关。
