地塞米松对去势母猪和公猪促性腺激素分泌的影响。
Effect of dexamethasone on gonadotrophin secretion in the gonadectomized sow and boar.
作者信息
Frautschy S A, Gaon D, Liptrap R M
机构信息
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph.
出版信息
Can J Vet Res. 1989 Oct;53(4):490-2.
Saline solution or dexamethasone (DXM, 35 micrograms/kg bodyweight) was injected intramuscularly twice daily for four days into five ovariectomized sows and five castrated boars. Blood samples from an indwelling jugular vein catheter were taken at 15 min intervals for 12 h prior to DXM injection and on the fourth day of treatment in order to compare the effect on variables describing the pulsatile secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Dexamethasone treatment caused a decrease (p less than 0.05) in the number of pulsatile episodes of LH secretion in both gonadectomized boars and sows resulting in a significant decrease in mean concentrations. Follicle stimulating hormone secretion parameters appeared to be unaffected by DXM injection in both groups of animals. It is concluded that previously described differences in LH suppression in boars and sows given glucocorticoids may be attributed to the influence of gonadal hormones.
将生理盐水或地塞米松（DXM，35微克/千克体重）每天两次肌肉注射到5头去卵巢母猪和5头去势公猪体内，持续4天。在注射DXM前12小时，每隔15分钟从颈静脉留置导管采集血样，并在治疗的第四天采集血样，以比较对描述促黄体生成素（LH）和促卵泡激素（FSH）脉冲分泌的变量的影响。地塞米松治疗导致去势公猪和母猪中LH分泌脉冲次数减少（p<0.05），导致平均浓度显著降低。两组动物中，FSH分泌参数似乎不受DXM注射的影响。得出的结论是，先前描述的给予糖皮质激素的公猪和母猪在LH抑制方面的差异可能归因于性腺激素的影响。
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