Fuquay J W, Moberg G P
J Endocrinol. 1983 Oct;99(1):151-5. doi: 10.1677/joe.0.0990151.
Treatment of intact rams with ACTH increased plasma corticosteroids and significantly reduced the ability of LH releasing hormone (LHRH) to elicit the release of LH. Infusion of cortisol at a rate which increased plasma corticosteroid concentrations to above that observed after injection of ACTH did not affect the ability of LHRH to induce the release of LH. In adrenalectomized rams LH release in response to LHRH was inhibited during ACTH treatment but was not affected in the absence of ACTH. Therefore, ACTH reduced the responsiveness of the anterior pituitary gland to LHRH through a mechanism not involving the adrenal gland.
用促肾上腺皮质激素（ACTH）处理未阉割的公羊，可使血浆皮质类固醇增加，并显著降低促黄体生成素释放激素（LHRH）引发促黄体生成素（LH）释放的能力。以能使血浆皮质类固醇浓度升至高于注射ACTH后所观察到的水平的速率输注皮质醇，并不会影响LHRH诱导LH释放的能力。在切除肾上腺的公羊中，ACTH处理期间LHRH诱导的LH释放受到抑制，但在没有ACTH时则不受影响。因此，ACTH通过一种不涉及肾上腺的机制降低了垂体前叶对LHRH的反应性。
