Crane I J, Patel V, Scully C, Prime S S
Department of Oral Medicine, Surgery and Pathology, University of Bristol Dental School, UK.
Carcinogenesis. 1989 Dec;10(12):2375-7. doi: 10.1093/carcin/10.12.2375.
Using the rat model of oral carcinogenesis in which cell lines were derived from tissue after in vivo and in vitro treatment with the carcinogen 4-nitroquinoline-N-oxide (4NQO), we have shown that aneuploidy is generally associated with the ability of cells to form colonies in an anchorage-independent environment and to form tumours in athymic mice. In one cell line derived from 4NQO treatment in vitro, there was evidence that aneuploidy was an early marker, preceding anchorage independence and tumorigenicity in athymic mice. However, this was an inconsistent finding in other cell lines and the use of aneuploidy as an early marker of pre-malignancy should be treated with caution.
利用口腔癌发生的大鼠模型，其中细胞系来源于用致癌物4-硝基喹啉-N-氧化物（4NQO）进行体内和体外处理后的组织，我们已经表明非整倍体通常与细胞在非锚定依赖环境中形成集落以及在无胸腺小鼠中形成肿瘤的能力相关。在一个来源于体外4NQO处理的细胞系中，有证据表明非整倍体是一个早期标志物，先于无胸腺小鼠中的锚定非依赖性和致瘤性。然而，这在其他细胞系中是一个不一致的发现，并且将非整倍体用作癌前病变的早期标志物应谨慎对待。
