系统性硬化症患者的免疫病理学发现：临床与免疫病理学关系

Immunopathologic findings in systemic sclerosis patients: clinical and immunopathologic relationships.

作者信息

Shibeshi D, Blaszczyk M, Jarzabek-Chorzelska M, Jablońska S, Chorzelski T

机构信息

Department of Dermatology, Warsaw School of Medicine, Poland.

出版信息

Int J Dermatol. 1989 Dec;28(10):650-6. doi: 10.1111/j.1365-4362.1989.tb02435.x.

DOI:10.1111/j.1365-4362.1989.tb02435.x

PMID:2512263

Abstract

Direct immunofluorescence (DIF) of the skin biopsy specimens was performed in 62 patients with systemic scleroderma: 26 cases of acrosclerosis (group 1), 26 cases of diffuse scleroderma (group 2) and ten cases of transitional form acrosclerosis-diffuse scleroderma (group 3). If epidermal nuclear fluorescence and lupus band test (LBT) were considered, the results were positive in 15.3% in group 1, 42.3% in group 2, and 10% in group 3. LBT was positive in 13.5% of the cases in groups 1 and 2 and negative in group 3. The immunoglobulin deposits at the dermoepidermal consisted mainly of IgM or a combination of IgG and IgM. There was no correlation between the LBT and antinuclear antibodies as detected by indirect immunofluorescence (IIF) or double immunodiffusion (DID).

摘要

对62例系统性硬化症患者的皮肤活检标本进行了直接免疫荧光（DIF）检查：26例肢端硬化症患者（第1组），26例弥漫性硬化症患者（第2组），以及10例肢端硬化症-弥漫性硬化症过渡型患者（第3组）。若考虑表皮核荧光和狼疮带试验（LBT），结果显示第1组阳性率为15.3%，第2组为42.3%，第3组为10%。第1组和第2组中13.5%的病例LBT呈阳性，第3组为阴性。真皮表皮交界处的免疫球蛋白沉积主要为IgM或IgG与IgM的组合。LBT与间接免疫荧光（IIF）或双向免疫扩散（DID）检测的抗核抗体之间无相关性。