体质性身材高大儿童生长激素（GH）对促甲状腺激素释放激素（TRH）的矛盾反应涉及一条胆碱能途径。

The paradoxical response of growth hormone (GH) to thyrotropin-releasing hormone (TRH) in constitutionally tall children involves a cholinergic pathway.

作者信息

Arteaga E, Valenzuelaa P, Cattani A, del Valle M

机构信息

Departamento de Endocrinologia, Pontificia Universidad Catolica de Chile, Santiago.

出版信息

J Endocrinol Invest. 1989 Sep;12(8):543-8. doi: 10.1007/BF03350756.

DOI:10.1007/BF03350756

PMID:2512341

Abstract

To investigate whether or not a cholinergic pathway is involved in the paradoxical response of GH to TRH in constitutionally tall children, we studied 8 healthy prepubertal children aged 4 2/12-7 10/12 yr, whose heights were over the 95th percentile of the NCHS tables. We defined as "paradoxical" a GH increment greater than 5 ng/ml in response to TRH. Five out of 8 children showed a paradoxical response of GH to TRH (mean GH peak after TRH of 10.7 +/- 1.1 ng/ml). Pretreatment with atropine (0.01 mg/kg IM 30 min prior to the TRH administration) abolished the TRH induced GH rise (peak GH after TRH of 1.5 +/- 1.0 ng/ml, p less than 0.01) but did not modify the TSH response (peak TSH after TRH: basal conditions 8.7 +/- 0.8 microU/ml, post atropine: 9.5 +/- 1.4 microU/ml, p greater than 0.05). Our results demonstrate that a cholinergic pathway is involved in the paradoxical response of GH to TRH in constitutionally tall children.

摘要

为了研究胆碱能通路是否参与体质性身材高大儿童中生长激素（GH）对促甲状腺激素释放激素（TRH）的反常反应，我们对8名健康的青春前期儿童进行了研究，他们的年龄在4岁2/12至7岁10/12岁之间，身高超过了美国国家卫生统计中心（NCHS）表格的第95百分位数。我们将对TRH反应时GH增加值大于5 ng/ml定义为“反常”。8名儿童中有5名表现出GH对TRH的反常反应（TRH后GH平均峰值为10.7±1.1 ng/ml）。在给予TRH前30分钟肌内注射阿托品（0.01 mg/kg）预处理消除了TRH诱导的GH升高（TRH后GH峰值为1.5±1.0 ng/ml，p<0.01），但未改变促甲状腺激素（TSH）反应（TRH后TSH峰值：基础状态下为8.7±0.8 μU/ml，阿托品处理后为9.5±1.4 μU/ml，p>0.05）。我们的结果表明，胆碱能通路参与了体质性身材高大儿童中GH对TRH的反常反应。