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Blockade of hp-GRF-40-induced GH release in normal men by a cholinergic muscarinic antagonist.

作者信息

Massara F, Ghigo E, Goffi S, Molinatti G M, Müller E E, Camanni F

出版信息

J Clin Endocrinol Metab. 1984 Nov;59(5):1025-6. doi: 10.1210/jcem-59-5-1025.

DOI:10.1210/jcem-59-5-1025
PMID:6434584
Abstract

In five healthy young men, pretreatment with the cholinergic muscarinic antagonist pirenzepine (0.6 mg/kg iv) almost completely abolished the rise in plasma growth hormone (GH) elicited by an iv bolus injection of 1 microgram/kg human pancreatic GH-releasing factor 1-40 (hp-GRF-40). These data demonstrate that cholinergic receptor sites involved in GH-releasing mechanisms do not interact with GRF-secreting structures in the central nervous system. A mechanism mediated via hypothalamic release of somatostatin or, alternatively, a direct pituitary site of action, can be postulated for the blocking effect of pirenzepine.

摘要

相似文献

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Blockade of hp-GRF-40-induced GH release in normal men by a cholinergic muscarinic antagonist.
J Clin Endocrinol Metab. 1984 Nov;59(5):1025-6. doi: 10.1210/jcem-59-5-1025.
2
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引用本文的文献

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