Blumenfeld J D, Grossman E B, Sun A M, Hebert S C
Laboratory of Kidney and Electrolyte Physiology, Brigham and Women's Hospital, Boston, Massachusetts.
Kidney Int. 1989 Sep;36(3):434-40. doi: 10.1038/ki.1989.213.
In conclusion, maintenance of volume homeostasis is a fundamental requirement of all cells. For many cell types, this process requires expression of ion cotransport mechanisms as well as accumulation of osmotically-active organic compounds. Recent observations have indicated that the cellular mechanisms responsible for modulating hypertonic volume regulation are complex and appear to involve hormonal, biochemical and physico-chemical stimuli. Knowledge of the specific ion-transport mechanisms involved in the initial phase of VRI, the factors that control their expression, and the interrelationships between inorganic and organic solute accumulation will be required before an in depth understanding of hypertonic cell volume regulation in medullary nephron segments can be achieved.
总之，维持容量稳态是所有细胞的基本需求。对于许多细胞类型而言，这一过程需要离子协同转运机制的表达以及渗透活性有机化合物的积累。最近的观察表明，负责调节高渗性容量调节的细胞机制很复杂，似乎涉及激素、生化和物理化学刺激。在深入了解髓质肾单位节段的高渗性细胞容量调节之前，需要了解参与VRI初始阶段的特定离子转运机制、控制其表达的因素以及无机和有机溶质积累之间的相互关系。
