Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada.
Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Centre for Addiction & Mental Health, Toronto, Ontario, Canada.
Psychiatry Res. 2014 Dec 15;220(1-2):245-50. doi: 10.1016/j.psychres.2014.06.053. Epub 2014 Jul 10.
Decrements in cognitive function are a common feature of Major Depressive Disorder (MDD), and whether distinct classes of antidepressants differentially affect memory in these individuals has not been sufficiently evaluated. In this study we sought to determine the effect of escitalopram and bupropion XL on memory and psychosocial function. Forty-one individuals (18-50 years) with MDD were enrolled in an 8-week, double-blind, double-dummy, randomized controlled comparative trial of bupropion XL and escitalopram. Thirty-six participants completed pre and post memory assessments. Verbal, non-verbal and working memory were evaluated with a comprehensive neuropsychological battery. Psychosocial function was assessed with the Sheehan Disability Scale and Endicott Work Productivity Scale. Escitalopram and bupropion XL significantly improved immediate as well as delayed verbal and nonverbal memory, global function (all p≤0.001), and work productivity (p=0.045), with no significant between-group differences. Improvement in immediate verbal memory exerted a direct influence on improvement in global function (p=0.006). Treatment with either escitalopram or bupropion XL was associated with improvement in memory and psychosocial function in adults with MDD.
认知功能下降是重度抑郁症（MDD）的一个常见特征，不同类别的抗抑郁药是否会对这些患者的记忆产生不同的影响尚未得到充分评估。在这项研究中，我们旨在确定艾司西酞普兰和安非他酮 XL 对记忆和社会心理功能的影响。41 名（18-50 岁）患有 MDD 的患者参加了为期 8 周的、双盲、双模拟、随机对照比较试验，比较安非他酮 XL 和艾司西酞普兰的疗效。36 名参与者完成了记忆评估的前后测试。采用全面的神经心理测验评估言语、非言语和工作记忆。采用 Sheehan 残疾量表和 Endicott 工作效率量表评估社会心理功能。艾司西酞普兰和安非他酮 XL 均显著改善了即刻和延迟的言语和非言语记忆、总体功能（所有 p≤0.001）和工作效率（p=0.045），且两组间无显著差异。即刻言语记忆的改善对总体功能的改善有直接影响（p=0.006）。艾司西酞普兰或安非他酮 XL 治疗与 MDD 成人的记忆和社会心理功能改善有关。
