Lorenzana-Bautista Ileana, Flores-Plascencia Aníbal, Barrios-Pineda Francisco Javier, Alderete-Vázquez Georgia, Sánchez-Valdivieso Enrique Alejandro
Departamento de Cirugía, Hospital Regional de Alta Especialidad de Veracruz, Secretaría de Salud, Veracruz, Mexico.
Departamento de Enseñanza, Hospital Regional de Alta Especialidad de Veracruz, Secretaría de Salud, Veracruz, Mexico.
Cir Cir. 2013 Sep-Oct;81(5):373-82.
A significant number of people suffer iatrogenic bile duct injury during laparoscopic cholescystectomy. Biliary-digestive bypass may be complicated by stenosis and biliary sepsis, affecting both quality of life and life expectancy. To avoid bypass synthetic grafts have been used, which are expensive.
Evaluating autologous implantation of peritoneus as alternative of bile duct repair.
Under general anesthesia, ten New Zealand adult rabbits were operated, common bile duct approached and sectioned underneath the cystic duct followed by a liver biopsy. An autologous graft was built of peritoneum and graft-bile duct proximal and distal end-to-end anastomosis done. Animals were followed-up by weekly bilirrubin and transferases. Rabbits were scheduled euthanized and a liver biopsy done for histological examinations.
Autologous graft was easy to create and all rabbits survived. They did not develop jaundice or alterations in their normal habits. At necropsy, autologous grafts were removed and no signs of occlusion were noticed. Moderate short-term liver damage was observed but long-term damage was negligible. Bileoma and pyogenic liver abscess were observed in two animals, respectively.
Our results favourably match well-known procedures used for bile duct repair, especially in cases of severe injury (Bismuth-Strasberg E1-3): it seems less complicated than biliary-digestive bypass, not as expensive as synthetic grafts, and much easier to build than human amnion graft.
Interposing an autologous graft of peritoneum is an easy-to-create surgical procedure and circumferential bile duct injuries were adequately repaired.
大量患者在腹腔镜胆囊切除术中遭受医源性胆管损伤。胆肠吻合术可能会并发狭窄和胆系感染,影响生活质量和预期寿命。为避免吻合术,已使用合成移植物,但价格昂贵。
评估自体腹膜植入作为胆管修复的替代方法。
在全身麻醉下,对10只成年新西兰兔进行手术,显露胆总管并在胆囊管下方切断,随后进行肝活检。用腹膜构建自体移植物,并将移植物与胆管近端和远端进行端对端吻合。每周检测胆红素和转氨酶对动物进行随访。安排对兔子实施安乐死并进行肝活检以进行组织学检查。
自体移植物易于构建,所有兔子均存活。它们未出现黄疸或正常习性改变。尸检时,取出自体移植物,未发现阻塞迹象。观察到中度短期肝损伤,但长期损伤可忽略不计。分别在两只动物中观察到胆汁瘤和化脓性肝脓肿。
我们的结果与用于胆管修复的知名手术效果良好匹配,尤其是在严重损伤(Bismuth-Strasberg E1-3)的情况下:它似乎比胆肠吻合术并发症少,不像合成移植物那么昂贵,并且比人羊膜移植物更容易构建。
置入自体腹膜移植物是一种易于实施的手术方法,可充分修复胆管环周损伤。