在胰腺黏液性囊腺瘤中存在间皮素表达。

Mesothelin expression in pancreatic mucinous cysts.

机构信息

From the Departments of Pathology and Laboratory Medicine and.

Department of Pathology, University of Alabama at Birmingham.

出版信息

Am J Clin Pathol. 2014 Sep;142(3):313-9. doi: 10.1309/AJCPDTTL2I5ECMFG.

DOI:10.1309/AJCPDTTL2I5ECMFG

PMID:25125620

Abstract

OBJECTIVES

Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma.

METHODS

From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was performed on representative sections.

RESULTS

MSLN was seen more frequently in neoplastic epithelial cells from IPMN (39/52; P < .0005) and MCN (9/14; P < .0001) compared with unremarkable adjacent pancreatic and bile ducts (0/57) and benign foveolar and duodenal epithelium (0/21). When present, MSLN was diffusely expressed in neoplastic epithelium and only focally expressed in adjacent ducts (8/57). No significant difference was seen (P = .26) in MLSN expression between IPMN (79%) and MCN (83%) when only presence or absence was considered.

CONCLUSION

Our findings suggest that MLSN can be used as a marker of neoplastic transformation of epithelial cells in pancreatic mucinous cysts. The findings can help identify neoplastic mucinous epithelium.

摘要

目的

间皮素 (MSLN) 是一种分化抗原，在导管内乳头状黏液性肿瘤 (IPMN) 中过度表达，是胰腺导管腺癌的潜在治疗靶点。

方法

从机构档案中确定了 114 例切除的胰腺黏液性囊肿病例，包括 IPMN 和黏液性囊腺瘤 (MCN)。对代表性切片进行 MSLN 的免疫组织化学分析。

结果

与无明显异常的相邻胰腺和胆管 (0/57) 和良性滤泡和十二指肠上皮 (0/21) 相比，MSLN 在 IPMN (39/52；P<.0005) 和 MCN (9/14；P<.0001) 的肿瘤上皮细胞中更为常见。当存在时，MSLN 在肿瘤上皮中呈弥漫性表达，仅在相邻导管中呈局灶性表达 (8/57)。当仅考虑存在或不存在时，MSLN 在 IPMN (79%) 和 MCN (83%) 之间的表达没有显著差异 (P=.26)。