特发性复发性流产患者子宫内膜中促前列腺素素 1 和白血病抑制因子 mRNA 的表达。
Prokineticin 1 and leukemia inhibitory factor mRNA expression in the endometrium of women with idiopathic recurrent pregnancy loss.
机构信息
Department of Obstetrics and Gynecology, Inonu University, School of Medicine, Malatya, Turkey.
Department of Medical Biology and Genetics, Inonu University, School of Medicine, Malatya, Turkey.
出版信息
Fertil Steril. 2014 Oct;102(4):1091-1095.e1. doi: 10.1016/j.fertnstert.2014.07.010. Epub 2014 Aug 13.
OBJECTIVE
To determine the expression patterns of prokineticin 1 (PROK1) and leukemia inhibitory factor (LIF) mRNA differ in peri-implantation endometrial tissue of women with idiopathic recurrent pregnancy loss (RPL) from normal fertile women.
DESIGN
A case-control study.
SETTING
University-based tertiary care center.
PATIENT(S): 30 women with idiopathic RPL and 30 fertile controls.
INTERVENTION(S): Endometrial biopsies.
MAIN OUTCOME MEASURE(S): Real-time polymerase chain reaction analysis for expression of PROK1 and LIF mRNA.
RESULT(S): The expression of PROK1 and LIF was statistically significantly increased in the endometrium of the women with idiopathic RPL compared with the controls. Furthermore, increased LIF expression was observed in the endometrium of women with idiopathic RPL compared with controls.
CONCLUSION(S): An increased mRNA expression of PROK1 and LIF could be one of the several abnormalities characterizing the endometrium in women with RPL.
目的
确定前列腺素 1（PROK1）和白血病抑制因子（LIF）mRNA 在特发性复发性妊娠丢失（RPL）妇女和正常生育妇女的着床期子宫内膜组织中的表达模式是否不同。
设计
病例对照研究。
地点
大学三级保健中心。
患者
30 例特发性 RPL 妇女和 30 例生育力正常对照。
干预措施
子宫内膜活检。
主要观察指标
实时聚合酶链反应分析 PROK1 和 LIF mRNA 的表达。
结果
与对照组相比，特发性 RPL 妇女的子宫内膜中 PROK1 和 LIF 的表达明显增加。此外，与对照组相比，特发性 RPL 妇女的子宫内膜中 LIF 的表达增加。
结论
PROK1 和 LIF 的 mRNA 表达增加可能是 RPL 妇女子宫内膜的几种异常特征之一。
Zotero 插件