Avram Dorina, Califano Danielle
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208.
J Immunol. 2014 Sep 1;193(5):2059-65. doi: 10.4049/jimmunol.1400930.
The transcription factor Bcl11b is expressed in all T cell subsets and progenitors, starting from the DN2 stage of T cell development, and it regulates critical processes implicated in the development, function, and survival of many of these cells. Among the common roles of Bcl11b in T cell progenitors and mature T cell subsets are the repression of the innate genetic program and, to some extent, expression maintenance of TCR-signaling components. However, Bcl11b also has unique roles in specific T cell populations, suggesting that its functions depend on cell type and activation state of the cell. In this article, we provide a comprehensive review of the roles of Bcl11b in progenitors, effector T cells, regulatory T cells, and invariant NKT cells, as well as its impact on immune diseases. While emphasizing common themes, including some that might be extended to skin and neurons, we also describe the control of specific functions in different T cell subsets.
转录因子Bcl11b在所有T细胞亚群和祖细胞中均有表达，从T细胞发育的DN2阶段开始，它调节许多这类细胞的发育、功能和存活所涉及的关键过程。Bcl11b在T细胞祖细胞和成熟T细胞亚群中的常见作用包括抑制先天遗传程序，以及在一定程度上维持TCR信号成分的表达。然而，Bcl11b在特定T细胞群体中也具有独特作用，这表明其功能取决于细胞类型和细胞的激活状态。在本文中，我们全面综述了Bcl11b在祖细胞、效应T细胞、调节性T细胞和不变自然杀伤T细胞中的作用，以及它对免疫疾病的影响。在强调共同主题（包括一些可能扩展到皮肤和神经元的主题）的同时，我们还描述了不同T细胞亚群中特定功能的调控。
