Anderson L A, McMullin M F
Centre for Public Health, Queen's University Belfast, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland,
Curr Hematol Malig Rep. 2014 Dec;9(4):340-9. doi: 10.1007/s11899-014-0228-z.
The myeloproliferative neoplasms, are characterised by overproduction of myeloid cells. Chronic myeloid leukaemia, polycythaemia vera, essential thrombocythaemia, myelofibrosis and the very rare disorders chronic neutrophilic leukaemia, chronic eosinophilic leukaemia not otherwise specified and mastocytosis are all included in the group. Incidence and prevalence rates reported in the worldwide literature are presented in this review. Survival data on each condition is described. Information on the aetiology of the disorders is discussed including body mass index, diet, smoking and alcohol, allergies, associated medical conditions, occupation and environmental exposures with focus on recent new studies. The aetiology of the myeloproliferative neoplasms remains unknown, and this review of the current state of knowledge highlights the need for further comprehensive research.
骨髓增殖性肿瘤的特征是髓系细胞过度生成。慢性髓性白血病、真性红细胞增多症、原发性血小板增多症、骨髓纤维化以及非常罕见的疾病慢性中性粒细胞白血病、未另行指定的慢性嗜酸性粒细胞白血病和肥大细胞增多症均包含在该组中。本综述介绍了全球文献报道的发病率和患病率。描述了每种疾病的生存数据。讨论了有关这些疾病病因的信息，包括体重指数、饮食、吸烟和饮酒、过敏、相关疾病、职业和环境暴露，并重点关注最近的新研究。骨髓增殖性肿瘤的病因仍然不明，对当前知识状态的这一综述强调了进一步进行全面研究的必要性。
