Fan Zhi-Xing, Yang Jian
Department of Cardiology, the First College of Clinical Medical Sciences, China Three Gorges University, Yichang, China. E-mail.
Saudi Med J. 2014 Aug;35(8):796-801.
Microribonucleic acids (miRNAs) are small non-coding RNAs, which control diverse cellular functions by either promoting degradation or inhibiting target messenger RNA translation. An aberrant expression profile of miRNAs has been linked to human diseases, including cardiovascular dysfunction. This review summarizes the latest insights in the identification of vascular-specific miRNAs and the underlying mechanisms for their roles in vascular restenosis mainly by influencing the proliferation and migration of vascular smooth muscle cell. Here, we discuss miRNA-based drug and gene therapy in vascular restenosis.
微小核糖核酸（miRNA）是一类小的非编码RNA，其通过促进降解或抑制靶信使核糖核酸的翻译来控制多种细胞功能。miRNA的异常表达谱与包括心血管功能障碍在内的人类疾病有关。本综述主要通过影响血管平滑肌细胞的增殖和迁移，总结了在血管特异性miRNA的鉴定及其在血管再狭窄中作用的潜在机制方面的最新见解。在此，我们讨论了基于miRNA的血管再狭窄药物和基因治疗。
